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Side effects of topical steroid use fall into two categories: Systemic side effects and local side effects. While systemic effects tend to occur more commonly than local side effects, systemic side effects are not uncommon either. In the absence of any known mechanism of this phenomenon, systemic side effects such as acne, rash, dryness, itching, headache, and depression due to steroid use is not uncommon. It is important to distinguish these systemic side effects from those that arise from local side effects as well as adverse effects caused by specific drug preparations, such as topical corticosteroids (capsaicin). Table 12.5 presents a list of selected cases of adverse effects associated with topical steroid use that are not specific to any specific local drug (Figure 1). TABLE 12.5 - Selected Adverse Effects Associated with Topical Steroid Use There is some concern that topical steroid use may increase the risk of developing skin cancer in certain individuals. The role of topical steroids in skin cancer has been examined in a number of publications over the last few years in both pre- and post-marketing research. For example, both an international and systematic review by Regan et al. (2005) and a randomized, double-blind, placebo-controlled pilot study conducted on patients with skin cancer in which only topical steroids were used, showed no increased cancer rate in those treated with topical steroids compared to those who did not receive topical steroids, regardless of age, cancer type, or duration of treatment. However, a case-control study by Hurd et al. (2002) demonstrated that men (n = 15) who used hormonal contraception (oral contraceptives) were at increased risk of developing ovarian and rectal cancers. The increase in risk was apparent in the first 3 years of using hormonal contraception compared to those not using hormonal contraceptives and was apparent in all study participants and in those women using hormonal contraceptives consistently (Table 12.6). Table 12.6 - Selected Observations on the Potential of Topical Steroid Use for Skin Cancer in Pregnancy or Maternal Use in Men and Women In addition to the increased risk of skin cancers associated with topical use of topical corticosteroids, there have been other safety concerns associated with the use of topical steroid (including topical steroids and topical retinoids) in pregnant or nursing women. In several studies, pregnancy was not listed as a contraindication to topical corticosteroids use, with some exceptions including the use of topical corticosteroids during pregnancy that have been shown to cause adverse effects. This appears to be due in part to the fact that the benefits of pregnancy can be more easily achieved Similar articles:
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